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The first CD73-instructed supramolecular hydrogel
#MMPMID25524006
Wu D
; Du X
; Shi J
; Zhou J
; Zhou N
; Xu B
J Colloid Interface Sci
2015[Jun]; 447
(?): 269-72
PMID25524006
show ga
Enzymatic supramolecular hydrogelation is a simple, controllable, and novel
strategy for preparation of soft colloidal materials, which allows the
integration of self-assembly with enzyme associated biological processes. The
development of more enzymes involve in hydrogelation is a subject of developing
useful soft colloids. In this work, an ectoenzyme, CD73, was found to trigger the
formation of nanofibers as matrices of hydrogels. CD73 is an important cell
surface enzyme which converts extracellular adenosine monophosphate (AMP) to
adenosine. It is broadly expressed in many cancer cells and participates in tumor
growth. The successful application of CD73 in self-assembly and hydrogelation may
provide new strategies for CD73-guided materials and therapies.