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2014 ; 21
(9
): 1059-65
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The expanding view of RNA and DNA function
#MMPMID25237854
Breaker RR
; Joyce GF
Chem Biol
2014[Sep]; 21
(9
): 1059-65
PMID25237854
show ga
RNA and DNA are simple linear polymers consisting of only four major types of
subunits, and yet these molecules carry out a remarkable diversity of functions
in cells and in the laboratory. Each newly discovered function of natural or
engineered nucleic acids enforces the view that prior assessments of nucleic acid
function were far too narrow and that many more exciting findings are yet to
come. This Perspective highlights just a few of the numerous discoveries over the
past 20 years pertaining to nucleic acid function, focusing on those that have
been of particular interest to chemical biologists. History suggests that there
will continue to be many opportunities to engage chemical biologists in the
discovery, creation, and manipulation of nucleic acid function in the years to
come.
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