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2016 ; 28
(1
): 58-64
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The evolving Gleason grading system
#MMPMID27041927
Chen N
; Zhou Q
Chin J Cancer Res
2016[Feb]; 28
(1
): 58-64
PMID27041927
show ga
The Gleason grading system for prostate adenocarcinoma has evolved from its
original scheme established in the 1960s-1970s, to a significantly modified
system after two major consensus meetings conducted by the International Society
of Urologic Pathology (ISUP) in 2005 and 2014, respectively. The Gleason grading
system has been incorporated into the WHO classification of prostate cancer, the
AJCC/UICC staging system, and the NCCN guidelines as one of the key factors in
treatment decision. Both pathologists and clinicians need to fully understand the
principles and practice of this grading system. We here briefly review the
historical aspects of the original scheme and the recent developments of Gleason
grading system, focusing on major changes over the years that resulted in the
modern Gleason grading system, which has led to a new "Grade Group" system
proposed by the 2014 ISUP consensus, and adopted by the 2016 WHO classification
of tumours of the prostate.
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