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10.1038/nrg.2016.170 http://scihub22266oqcxt.onion/10.1038/nrg.2016.170 C5886015!5886015 !28190876     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28190876 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Genet 2017 ; 18 (4 ): 213-229 Nephropedia Template TP {{tp|p=28190876 |t=2017. The evolution of tumour phylogenetics: principles and practice |pdf=|usr=}}{{28190876 }} gab.com Text The evolution of tumour phylogenetics: principles and practice JO: Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=28190876 #FOAvip Rapid advances in high-throughput sequencing and a growing realization of the importance of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies of tumour progression. These studies have yielded not only new insights but also a plethora of experimental approaches, sometimes reaching conflicting or poorly supported conclusions. Here, we consider this body of work in light of the key computational principles underpinning phylogenetic inference, with the goal of providing practical guidance on the design and analysis of scientifically rigorous tumour phylogeny studies. We survey the range of methods and tools available to the researcher, their key applications, and the various unsolved problems, closing with a perspective on the prospects and broader implications of this field. Twit Text FOAVip The evolution of tumour phylogenetics: principles and practice ????Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=28190876 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28190876 #FOAvip English Wikipedia <ref>{{Cite pmid|28190876 }}</ref> The evolution of tumour phylogenetics: principles and practice #MMPMID28190876 Schwartz R ; Schäffer AA Nat Rev Genet 2017[Apr]; 18 (4 ): 213-229 PMID28190876 show ga Rapid advances in high-throughput sequencing and a growing realization of the importance of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies of tumour progression. These studies have yielded not only new insights but also a plethora of experimental approaches, sometimes reaching conflicting or poorly supported conclusions. Here, we consider this body of work in light of the key computational principles underpinning phylogenetic inference, with the goal of providing practical guidance on the design and analysis of scientifically rigorous tumour phylogeny studies. We survey the range of methods and tools available to the researcher, their key applications, and the various unsolved problems, closing with a perspective on the prospects and broader implications of this field. |*Biological Evolution [MESH] |*Phylogeny [MESH] |Algorithms [MESH] |Animals [MESH] |Genomics/*methods [MESH] |High-Throughput Nucleotide Sequencing/*methods [MESH] |Humans [MESH]The evolution of tumour phylogenetics: principles and practice (epmc).pdf DeepDyve Pubget Overpricing