Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26710352
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26710352
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Blood+Transfus
2016 ; 14
(2
): 175-84
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The evolution of anticoagulant therapy
#MMPMID26710352
Franchini M
; Liumbruno GM
; Bonfanti C
; Lippi G
Blood Transfus
2016[Mar]; 14
(2
): 175-84
PMID26710352
show ga
Arterial and venous thromboembolism are leading causes of morbidity and mortality
around the world. For almost 70 years, heparins (unfractionated heparin and low
molecular weight heparins) and vitamin K antagonists have been the leading
therapeutic medical options for the treatment and prevention of thromboembolic
disorders. Nevertheless, the many limitations of these traditional anticoagulants
have fuelled the search for novel agents over the past 15 years, and a new class
of oral anticoagulants that specifically target activated factor X and thrombin
has been developed and is now commercially available. In this narrative review,
the evolution of anticoagulant therapy is summarised, with a focus on newer oral
anticoagulants.
|Administration, Oral
[MESH]
|Factor Xa Inhibitors/history/*therapeutic use
[MESH]