Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24359107
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24359107
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Antioxid+Redox+Signal
2014 ; 21
(3
): 485-96
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The emerging role of QSOX1 in cancer
#MMPMID24359107
Lake DF
; Faigel DO
Antioxid Redox Signal
2014[Jul]; 21
(3
): 485-96
PMID24359107
show ga
SIGNIFICANCE: Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme that oxidizes
thiols during protein folding, reducing molecular oxygen to hydrogen peroxide.
Tumor cells may take advantage of oxidative environments at different stages of
tumorigenesis, but QSOX1 may also serve additional functions in tumors. RECENT
ADVANCES: Several groups have reported the over-expression of QSOX1 in breast,
pancreas, and prostate cancers. A consensus is building that QSOX1
over-expression is important during tumor cell invasion, facilitating tumor cell
migration at the tumor-stroma interface. As such, QSOX1 may be considered a
prognostic indicator of metastatic potential or even indicate that cancer is
present in a host. CRITICAL ISSUES: However, some controversy exists between
QSOX1 as a marker of poor or favorable outcome in breast cancer. More studies are
required to reveal what advantage QSOX1 provides to breast and other types of
cancer. More specifically, it is critical to learn which tumor types over-express
QSOX1 and use its enzymatic activity to their advantage. FUTURE DIRECTIONS: As
interest increases in understanding the mechanisms of tumorigenesis within the
extracellular matrix and how tumor cells influence fibroblasts and other stromal
cells, QSOX1 may be revealed as an important player in cancer detection and
prognosis. Defining the mechanism(s) of QSOX1 activity in tumors and in in vivo
models will provide important insights into how to target QSOX1 with
anti-neoplastic agents.
free
free
free
