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2014 ; 6
(3
): 198-205
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The dichotomy of p53 regulation by noncoding RNAs
#MMPMID24706938
Deng Q
; Becker L
; Ma X
; Zhong X
; Young K
; Ramos K
; Li Y
J Mol Cell Biol
2014[Jun]; 6
(3
): 198-205
PMID24706938
show ga
The p53 tumor suppressor gene is the most frequently mutated gene in cancer.
Significant progress has been made to discern the importance of p53 in
coordinating cellular responses to DNA damage, oncogene activation, and other
stresses. Noncoding RNAs are RNA molecules functioning without being translated
into proteins. In this work, we discuss the dichotomy of p53 regulation by
noncoding RNAs with four unconventional questions. First, is overexpression of
microRNAs responsible for p53 inactivation in the absence of p53 mutation?
Second, are there somatic mutations in the noncoding regions of the p53 gene?
Third, is there a germline mutant in the noncoding regions of the p53 gene that
predisposes carriers to cancer? Fourth, can p53 activation mediated by a
noncoding RNA mutation cause cancer? This work highlights the prominence of
noncoding RNAs in p53 dysregulation and tumorigenesis.
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