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10.1016/j.cell.2014.05.016 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.05.016 C4184276!4184276 !24949970     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24949970 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2014 ; 157 (7 ): 1577-90 Nephropedia Template TP {{tp|p=24949970 |t=2014. The diabetes susceptibility gene Clec16a regulates mitophagy |pdf=|usr=}}{{24949970 }} gab.com Text The diabetes susceptibility gene Clec16a regulates mitophagy JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24949970 #FOAvip Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the Nrdp1 target Parkin, a master regulator of mitophagy. Islets from mice with pancreas-specific deletion of Clec16a have abnormal mitochondria with reduced oxygen consumption and ATP concentration, both of which are required for normal ? cell function. Indeed, pancreatic Clec16a is required for normal glucose-stimulated insulin release. Moreover, patients harboring a diabetogenic SNP in the Clec16a gene have reduced islet Clec16a expression and reduced insulin secretion. Thus, Clec16a controls ? cell function and prevents diabetes by controlling mitophagy. This pathway could be targeted for prevention and control of diabetes and may extend to the pathogenesis of other Clec16a- and Parkin-associated diseases. Twit Text FOAVip The diabetes susceptibility gene Clec16a regulates mitophagy ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24949970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24949970 #FOAvip English Wikipedia <ref>{{Cite pmid|24949970 }}</ref> The diabetes susceptibility gene Clec16a regulates mitophagy #MMPMID24949970 Soleimanpour SA ; Gupta A ; Bakay M ; Ferrari AM ; Groff DN ; Fadista J ; Spruce LA ; Kushner JA ; Groop L ; Seeholzer SH ; Kaufman BA ; Hakonarson H ; Stoffers DA Cell 2014[Jun]; 157 (7 ): 1577-90 PMID24949970 show ga Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the Nrdp1 target Parkin, a master regulator of mitophagy. Islets from mice with pancreas-specific deletion of Clec16a have abnormal mitochondria with reduced oxygen consumption and ATP concentration, both of which are required for normal ? cell function. Indeed, pancreatic Clec16a is required for normal glucose-stimulated insulin release. Moreover, patients harboring a diabetogenic SNP in the Clec16a gene have reduced islet Clec16a expression and reduced insulin secretion. Thus, Clec16a controls ? cell function and prevents diabetes by controlling mitophagy. This pathway could be targeted for prevention and control of diabetes and may extend to the pathogenesis of other Clec16a- and Parkin-associated diseases. |*Mitophagy [MESH] |Amino Acid Sequence [MESH] |Animals [MESH] |Carrier Proteins/chemistry [MESH] |Diabetes Mellitus, Type 1/*genetics/pathology [MESH] |Genetic Predisposition to Disease [MESH] |Glucose/metabolism [MESH] |Humans [MESH] |Insulin-Secreting Cells/metabolism [MESH] |Islets of Langerhans/metabolism/*pathology [MESH] |Lectins, C-Type/chemistry/genetics/*metabolism [MESH] |Lysosomes/chemistry/metabolism [MESH] |Membrane Proteins/metabolism [MESH] |Mice [MESH] |Molecular Sequence Data [MESH] |Monosaccharide Transport Proteins/chemistry/genetics/*metabolism [MESH] |Polymorphism, Single Nucleotide [MESH]The diabetes susceptibility gene Clec16a regulates mitophagy (epmc).pdf DeepDyve Pubget Overpricing