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10.1186/s12861-015-0094-5 http://scihub22266oqcxt.onion/10.1186/s12861-015-0094-5 C4654913!4654913 !26589542     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26589542 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Dev+Biol 2015 ; 15 (ä): 44 Nephropedia Template TP {{tp|p=26589542 |t=2015. The developmental basis of mesenchymal stem/stromal cells (MSCs) |pdf=|usr=}}{{26589542 }} gab.com Text The developmental basis of mesenchymal stem/stromal cells (MSCs) JO: BMC Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=26589542 #FOAvip BACKGROUND: Mesenchymal Stem/Stromal Cells (MSCs) define a population of progenitor cells capable of giving rises to at least three mesodermal lineages in vitro, the chondrocytes, osteoblasts and adipocytes. The validity of MSCs in vivo has been questioned because their existence, either as a homogeneous progenitor cell population or as a stem cell lineage, has been difficult to prove. The wide use of primary MSCs in regenerative and therapeutic applications raises ethical and regulatory concerns in many countries. In contrast to hematopoietic stem cells, a parallel concept which carries an embryological emphasis from its outset, MSCs have attracted little interest among developmental biologists and the embryological basis for their existence, or lack thereof, has not been carefully evaluated. METHODS: This article provides a brief, embryological overview of these three mesoderm cell lineages and offers a framework of ontological rationales for the potential existence of MSCs in vivo. RESULTS: Emphasis is given to the common somatic lateral plate mesoderm origin of the majority of body's adipose and skeletal tissues and of the major sources used for MSC derivation clinically. Support for the MSC hypothesis also comes from a large body of molecular and lineage analysis data in vivo. CONCLUSIONS: It is concluded that despite the lack of a definitive proof, the MSC concept has a firm embryological basis and that advances in MSC research can be facilitated by achieving a better integration with developmental biology. Twit Text FOAVip The developmental basis of mesenchymal stem/stromal cells (MSCs) ????BMC Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=26589542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26589542 #FOAvip English Wikipedia <ref>{{Cite pmid|26589542 }}</ref> The developmental basis of mesenchymal stem/stromal cells (MSCs) #MMPMID26589542 Sheng G BMC Dev Biol 2015[Nov]; 15 (ä): 44 PMID26589542 show ga BACKGROUND: Mesenchymal Stem/Stromal Cells (MSCs) define a population of progenitor cells capable of giving rises to at least three mesodermal lineages in vitro, the chondrocytes, osteoblasts and adipocytes. The validity of MSCs in vivo has been questioned because their existence, either as a homogeneous progenitor cell population or as a stem cell lineage, has been difficult to prove. The wide use of primary MSCs in regenerative and therapeutic applications raises ethical and regulatory concerns in many countries. In contrast to hematopoietic stem cells, a parallel concept which carries an embryological emphasis from its outset, MSCs have attracted little interest among developmental biologists and the embryological basis for their existence, or lack thereof, has not been carefully evaluated. METHODS: This article provides a brief, embryological overview of these three mesoderm cell lineages and offers a framework of ontological rationales for the potential existence of MSCs in vivo. RESULTS: Emphasis is given to the common somatic lateral plate mesoderm origin of the majority of body's adipose and skeletal tissues and of the major sources used for MSC derivation clinically. Support for the MSC hypothesis also comes from a large body of molecular and lineage analysis data in vivo. CONCLUSIONS: It is concluded that despite the lack of a definitive proof, the MSC concept has a firm embryological basis and that advances in MSC research can be facilitated by achieving a better integration with developmental biology. |Adipocytes/*cytology [MESH] |Adipogenesis/physiology [MESH] |Animals [MESH] |Bone Marrow Cells/cytology [MESH] |Cell Lineage/physiology [MESH] |Chondrocytes/*cytology [MESH] |Chondrogenesis/physiology [MESH] |Humans [MESH] |Mesenchymal Stem Cells/*cytology/physiology [MESH] |Mesoderm/*embryology [MESH] |Osteoblasts/*cytology [MESH]The developmental basis of mesenchymal stem/stromal cells (MSCs) (epmc).pdf DeepDyve Pubget Overpricing