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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Hum+Vaccin+Immunother
2016 ; 12
(3
): 794-800
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The cost effectiveness of rotavirus vaccination in Iran
#MMPMID26360331
Mousavi Jarrahi Y
; Zahraei SM
; Sadigh N
; Esmaeelpoor Langeroudy K
; Khodadost M
; Ranjbaran M
; Sanjari Moghaddam A
; Besharat M
; Mosavi Jarrahi A
Hum Vaccin Immunother
2016[Mar]; 12
(3
): 794-800
PMID26360331
show ga
Rotavirus is the most common cause of severe diarrhea leading to hospitalization
or disease-specific death among young children. Effective vaccines have recently
been approved and successful vaccination program implemented. The aim of this
study was to evaluate the cost effectiveness of mass rotavirus vaccination
program in Iran. We developed a Markov model that reflects key features of
rotavirus natural history. Parameters of the model were assessed by field study
or developed through literature search and published data. We applied the model
to the 2009 Iranian birth cohort and evaluated the cost-effectiveness of
including the rotavirus vaccine (Rotarix®) into Iranian expanded immunization
program (EPI). With an estimated hospitalization rate of 0.05 and outpatient rate
of 0.23 cases per person-year, vaccinating cohort of 1231735 infants in Iran with
2 doses of (Rotarix®), would prevent 32092 hospitalizations, 158750 outpatient
visits, and 1591 deaths during 5 y of follow-up. Under base-case assumption of
$10 cost per course of vaccine, the vaccination would incur an extra cost of
$1,019,192 from health care perspective and would avert 54680 DALYs. From
societal perspective, there would be $15,192,568 saving for the society with the
same averted DALYs. The incremental cost effectiveness ratio showed a cost of $19
US dollars per averted DALY from health care perspective and a saving of $278 US
dollars for each averted DALY from societal perspective. Introducing rotavirus
vaccine into EPI program would be highly cost-effective public health
intervention in Iran.
|*Cost-Benefit Analysis
[MESH]
|Child, Preschool
[MESH]
|Cohort Studies
[MESH]
|Humans
[MESH]
|Infant
[MESH]
|Infant, Newborn
[MESH]
|Iran/epidemiology
[MESH]
|Rotavirus Infections/*economics/epidemiology/*prevention & control
[MESH]
free
free
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