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10.1016/j.ddtec.2012.08.003 http://scihub22266oqcxt.onion/10.1016/j.ddtec.2012.08.003 C4101544!4101544 !25027380     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25027380 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Drug+Discov+Today+Technol 2014 ; 12 (ä): e9-e17 Nephropedia Template TP {{tp|p=25027380 |t=2014. The controversial world of sirtuins |pdf=|usr=}}{{25027380 }} gab.com Text The controversial world of sirtuins JO: Drug Discov Today Technol http://www.kidney.de/pget.php?&tw=1&pmid=25027380 #FOAvip The controversy around sirtuins and their functions in aging has drawn in the past few years as much attention, if not more, from the scientific community and the public as they did when first proposed as the key conserved aging regulators in eukaryotes. With some of the basic observations on sirtuin longevity promoting functions being questioned in popular model systems, researchers are wondering if this family of conserved enzymes still holds strong potential as therapeutic targets. This review examines the several controversial issues around sirtuins and their functions in aging, calorie restriction, as well as age-related diseases in light of recent studies in mammalian systems and discusses whether modulators of sirtuins still hold the secret of life.: Twit Text FOAVip The controversial world of sirtuins ????Drug Discov Today Technol http://www.kidney.de/pget.php?&tw=1&pmid=25027380 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25027380 #FOAvip English Wikipedia <ref>{{Cite pmid|25027380 }}</ref> The controversial world of sirtuins #MMPMID25027380 Dang W Drug Discov Today Technol 2014[Jun]; 12 (ä): e9-e17 PMID25027380 show ga The controversy around sirtuins and their functions in aging has drawn in the past few years as much attention, if not more, from the scientific community and the public as they did when first proposed as the key conserved aging regulators in eukaryotes. With some of the basic observations on sirtuin longevity promoting functions being questioned in popular model systems, researchers are wondering if this family of conserved enzymes still holds strong potential as therapeutic targets. This review examines the several controversial issues around sirtuins and their functions in aging, calorie restriction, as well as age-related diseases in light of recent studies in mammalian systems and discusses whether modulators of sirtuins still hold the secret of life.: |Aging/drug effects/*metabolism [MESH] |Animals [MESH] |Caloric Restriction [MESH] |Epigenesis, Genetic/genetics/physiology [MESH] |Humans [MESH] |Longevity/drug effects/genetics [MESH] |Resveratrol [MESH] |Sirtuins/genetics/*physiology [MESH]The controversial world of sirtuins (epmc).pdf DeepDyve Pubget Overpricing