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2018 ; 8
(4
): 566-583
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The contrasting roles of inflammasomes in cancer
#MMPMID29736304
He Q
; Fu Y
; Tian D
; Yan W
Am J Cancer Res
2018[]; 8
(4
): 566-583
PMID29736304
show ga
Chronic inflammation plays a decisive role at different stages of cancer
development. Inflammasomes are oligomeric protein complexes activated in response
to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular
patterns (DAMPs). PAMPs and DAMPs are released from infected cells, tumors and
damaged tissues. Inflammasomes activate and release inflammatory cytokines such
as IL-1? and IL-18. The various inflammasomes and inflammatory cytokines and
chemokines play contrasting roles in cancer development and progression. In this
review, we describe the roles of different inflammasomes in lung, breast,
gastric, liver, colon, and prostate cancers and in glioblastomas.