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2017 ; 93
(2
): 64-86
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The complexity of glycoprotein-derived glycans
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Vliegenthart JF
Proc Jpn Acad Ser B Phys Biol Sci
2017[]; 93
(2
): 64-86
PMID28190870
show ga
A brief review is presented of our studies on the structure of
glycoprotein-derived glycans. The emphasis is on the introduction of
high-resolution (1)H-NMR spectroscopy for the unambiguous determination of
primary structures. For this purpose, we developed the structural reporter group
concept. Structural reporters are defined as unique markers of structural
elements in the NMR spectra. Application of this concept led to the discovery of
numerous new structures. Furthermore, a number of structures presented in the
literature could be corrected. The results are relevant for insight in the
various steps in glycan metabolism in health and disease, for the function and
mode of action of glycans in vivo and for the interpretation of structural
information obtained through other techniques. The strength of the approach is
further shown for several highly complex glycoproteins, carrying very
heterogeneous and complicated glycans.
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