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The circadian coordination of cell biology
#MMPMID27738003
Chaix A
; Zarrinpar A
; Panda S
J Cell Biol
2016[Oct]; 215
(1
): 15-25
PMID27738003
show ga
Circadian clocks are cell-autonomous timing mechanisms that organize cell
functions in a 24-h periodicity. In mammals, the main circadian oscillator
consists of transcription-translation feedback loops composed of transcriptional
regulators, enzymes, and scaffolds that generate and sustain daily oscillations
of their own transcript and protein levels. The clock components and their
targets impart rhythmic functions to many gene products through transcriptional,
posttranscriptional, translational, and posttranslational mechanisms. This, in
turn, temporally coordinates many signaling pathways, metabolic activity,
organelles' structure and functions, as well as the cell cycle and the
tissue-specific functions of differentiated cells. When the functions of these
circadian oscillators are disrupted by age, environment, or genetic mutation, the
temporal coordination of cellular functions is lost, reducing organismal health
and fitness.
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