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2015 ; 7
(5
): ä Nephropedia Template TP
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The chemokine system in innate immunity
#MMPMID25635046
Sokol CL
; Luster AD
Cold Spring Harb Perspect Biol
2015[Jan]; 7
(5
): ä PMID25635046
show ga
Chemokines are chemotactic cytokines that control the migration and positioning
of immune cells in tissues and are critical for the function of the innate immune
system. Chemokines control the release of innate immune cells from the bone
marrow during homeostasis as well as in response to infection and inflammation.
They also recruit innate immune effectors out of the circulation and into the
tissue where, in collaboration with other chemoattractants, they guide these
cells to the very sites of tissue injury. Chemokine function is also critical for
the positioning of innate immune sentinels in peripheral tissue and then,
following innate immune activation, guiding these activated cells to the draining
lymph node to initiate and imprint an adaptive immune response. In this review,
we will highlight recent advances in understanding how chemokine function
regulates the movement and positioning of innate immune cells at homeostasis and
in response to acute inflammation, and then we will review how chemokine-mediated
innate immune cell trafficking plays an essential role in linking the innate and
adaptive immune responses.
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