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2014 ; 26
(ä): 142-8
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The chandelier cell, form and function
#MMPMID24556285
Inan M
; Anderson SA
Curr Opin Neurobiol
2014[Jun]; 26
(ä): 142-8
PMID24556285
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Among ?-aminobutyric acid (GABA) interneurons, the chandelier cell (ChC) has
captured the interest of neuroscientists for a very long time as a subtype not
described by Ramon y Cajal. ChCs feature an axonal arborization that selectively
innervates the axon initial segments of pyramidal cells. Recent studies involving
transgenic mice have identified intriguing features of ChCs, including a
remarkably specific spatial and temporal origins, their capacity to have either
excitatory or inhibitory influences on pyramidal neurons, and their synaptic
alterations in schizophrenia. This review explores these and other developmental
and functional aspects of this fascinating cortical neuronal subtype.