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10.1016/j.febslet.2013.05.020 http://scihub22266oqcxt.onion/10.1016/j.febslet.2013.05.020 C4471140!4471140 !23684651     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23684651 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FEBS+Lett 2013 ; 587 (13 ): 2008-17 Nephropedia Template TP {{tp|p=23684651 |t=2013. The cell stress machinery and retinal degeneration |pdf=|usr=}}{{23684651 }} gab.com Text The cell stress machinery and retinal degeneration JO: FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=23684651 #FOAvip Retinal degenerations are a group of clinically and genetically heterogeneous disorders characterised by progressive loss of vision due to neurodegeneration. The retina is a highly specialised tissue with a unique architecture and maintaining homeostasis in all the different retinal cell types is crucial for healthy vision. The retina can be exposed to a variety of environmental insults and stress, including light-induced damage, oxidative stress and inherited mutations that can lead to protein misfolding. Within retinal cells there are different mechanisms to cope with disturbances in proteostasis, such as the heat shock response, the unfolded protein response and autophagy. In this review, we discuss the multiple responses of the retina to different types of stress involved in retinal degenerations, such as retinitis pigmentosa, age-related macular degeneration and glaucoma. Understanding the mechanisms that maintain and re-establish proteostasis in the retina is important for developing new therapeutic approaches to fight blindness. Twit Text FOAVip The cell stress machinery and retinal degeneration ????FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=23684651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23684651 #FOAvip English Wikipedia <ref>{{Cite pmid|23684651 }}</ref> The cell stress machinery and retinal degeneration #MMPMID23684651 Athanasiou D ; Aguilą M ; Bevilacqua D ; Novoselov SS ; Parfitt DA ; Cheetham ME FEBS Lett 2013[Jun]; 587 (13 ): 2008-17 PMID23684651 show ga Retinal degenerations are a group of clinically and genetically heterogeneous disorders characterised by progressive loss of vision due to neurodegeneration. The retina is a highly specialised tissue with a unique architecture and maintaining homeostasis in all the different retinal cell types is crucial for healthy vision. The retina can be exposed to a variety of environmental insults and stress, including light-induced damage, oxidative stress and inherited mutations that can lead to protein misfolding. Within retinal cells there are different mechanisms to cope with disturbances in proteostasis, such as the heat shock response, the unfolded protein response and autophagy. In this review, we discuss the multiple responses of the retina to different types of stress involved in retinal degenerations, such as retinitis pigmentosa, age-related macular degeneration and glaucoma. Understanding the mechanisms that maintain and re-establish proteostasis in the retina is important for developing new therapeutic approaches to fight blindness. |*Stress, Physiological [MESH] |Animals [MESH] |Humans [MESH] |Mutation [MESH] |Proteostasis Deficiencies/metabolism/pathology/therapy [MESH] |Retina/metabolism/pathology [MESH] |Retinal Degeneration/*metabolism/pathology/therapy [MESH] |Retinal Pigment Epithelium/*metabolism/pathology [MESH] |Retinal Vessels/pathology [MESH]The cell stress machinery and retinal degeneration (epmc).pdf DeepDyve Pubget Overpricing