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10.1016/j.beem.2013.02.011 http://scihub22266oqcxt.onion/10.1016/j.beem.2013.02.011 C3713417!3713417 !23856268     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23856268 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23856268 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Best+Pract+Res+Clin+Endocrinol+Metab 2013 ; 27 (3 ): 403-14 Nephropedia Template TP {{tp|p=23856268 |t=2013. The calcium-sensing receptor in the breast |pdf=|usr=}}{{23856268 }} gab.com Text The calcium-sensing receptor in the breast JO: Best Pract Res Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=23856268 #FOAvip Normal breast epithelial cells and breast cancer cells express the calcium-sensing receptor (CaSR), the master regulator of systemic calcium metabolism. During lactation, activation of the CaSR in mammary epithelial cells downregulates parathyroid hormone-related protein (PTHrP) levels in milk and in the circulation, and increases calcium transport into milk. In contrast, in breast cancer cells the CaSR upregulates PTHrP production. A switch in G-protein usage underlies the opposing effects of the CaSR on PTHrP expression in normal and malignant breast cells. During lactation, the CaSR in normal breast cells coordinates a feedback loop that matches the transport of calcium into milk and maternal calcium metabolism to the supply of calcium. A switch in CaSR G-protein usage during malignant transformation converts this feedback loop into a feed-forward cycle in breast cancer cells that may promote the growth of osteolytic skeletal metastases. Twit Text FOAVip The calcium-sensing receptor in the breast ????Best Pract Res Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=23856268 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23856268 #FOAvip English Wikipedia <ref>{{Cite pmid|23856268 }}</ref> The calcium-sensing receptor in the breast #MMPMID23856268 Vanhouten JN ; Wysolmerski JJ Best Pract Res Clin Endocrinol Metab 2013[Jun]; 27 (3 ): 403-14 PMID23856268 show ga Normal breast epithelial cells and breast cancer cells express the calcium-sensing receptor (CaSR), the master regulator of systemic calcium metabolism. During lactation, activation of the CaSR in mammary epithelial cells downregulates parathyroid hormone-related protein (PTHrP) levels in milk and in the circulation, and increases calcium transport into milk. In contrast, in breast cancer cells the CaSR upregulates PTHrP production. A switch in G-protein usage underlies the opposing effects of the CaSR on PTHrP expression in normal and malignant breast cells. During lactation, the CaSR in normal breast cells coordinates a feedback loop that matches the transport of calcium into milk and maternal calcium metabolism to the supply of calcium. A switch in CaSR G-protein usage during malignant transformation converts this feedback loop into a feed-forward cycle in breast cancer cells that may promote the growth of osteolytic skeletal metastases. |Animals [MESH] |Breast/*metabolism [MESH] |Epithelial Cells/metabolism [MESH] |Female [MESH] |Humans [MESH] |Lactation/*metabolism [MESH] |Mammary Glands, Animal/metabolism [MESH] |Mammary Glands, Human/*metabolism [MESH] |Parathyroid Hormone-Related Protein/metabolism [MESH] |Receptors, Calcium-Sensing/genetics/*metabolism [MESH]The calcium-sensing receptor in the breast (epmc).pdf DeepDyve Pubget Overpricing