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10.15252/embr.201439834 http://scihub22266oqcxt.onion/10.15252/embr.201439834 C4388610!4388610!25722290     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25722290.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Rep 2015 ; 16 (4): 427-46 Nephropedia Template TP {{tp|p=25722290|t=2015. The biology of IQGAP proteins: beyond the cytoskeleton |pdf=|usr=}}{{25722290}} gab.com Text The biology of IQGAP proteins: beyond the cytoskeleton JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25722290 #FOAvip IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio-vascular system, pancreas, and lung. The functions of IQGAPs can be corrupted during oncogenesis and are usurped by microbial pathogens. Therefore, IQGAPs represent intriguing candidates for novel therapeutic agents. While modulation of the cytoskeletal architecture was initially thought to be the primary function of IQGAPs, it is now clear that they have roles beyond the cytoskeleton. This review describes contributions of IQGAPs to physiology at the organism level. Twit Text FOAVip The biology of IQGAP proteins: beyond the cytoskeleton ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25722290 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25722290 #FOAvip English Wikipedia <ref>{{Cite pmid|25722290}}</ref> The biology of IQGAP proteins: beyond the cytoskeleton #MMPMID25722290 Hedman AC; Smith JM; Sacks DB EMBO Rep 2015[Apr]; 16 (4): 427-46 PMID25722290show ga IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio-vascular system, pancreas, and lung. The functions of IQGAPs can be corrupted during oncogenesis and are usurped by microbial pathogens. Therefore, IQGAPs represent intriguing candidates for novel therapeutic agents. While modulation of the cytoskeletal architecture was initially thought to be the primary function of IQGAPs, it is now clear that they have roles beyond the cytoskeleton. This review describes contributions of IQGAPs to physiology at the organism level. äThe biology of IQGAP proteins: beyond the cytoskeleton (epmc).pdf DeepDyve Pubget Overpricing