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2015 ; 6
(11
): 8491-524
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The biology and treatment of oligometastatic cancer
#MMPMID25940699
Reyes DK
; Pienta KJ
Oncotarget
2015[Apr]; 6
(11
): 8491-524
PMID25940699
show ga
Clinical reports of limited and treatable cancer metastases, a disease state that
exists in a transitional zone between localized and widespread systemic disease,
were noted on occasion historically and are now termed oligometastasis. The
ramification of a diagnosis of oligometastasis is a change in treatment paradigm,
i.e. if the primary cancer site (if still present) is controlled, or resected,
and the metastatic sites are ablated (surgically or with radiation), a prolonged
disease-free interval, and perhaps even cure, may be achieved. Contemporary
molecular diagnostics are edging closer to being able to determine where an
individual metastatic deposit is within the continuum of malignancy. Preclinical
models are on the outset of laying the groundwork for understanding the
oligometastatic state. Meanwhile, in the clinic, patients are increasingly being
designated as having oligometastatic disease and being treated owing to improved
diagnostic imaging, novel treatment options with the potential to provide either
direct or bridging therapy, and progressively broad definitions of
oligometastasis.
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