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10.1172/JCI81135

http://scihub22266oqcxt.onion/10.1172/JCI81135
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C4811149!4811149 !27035812
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suck abstract from ncbi


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pmid27035812
      J+Clin+Invest 2016 ; 126 (4 ): 1208-15
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  • The biology and function of exosomes in cancer #MMPMID27035812
  • Kalluri R
  • J Clin Invest 2016[Apr]; 126 (4 ): 1208-15 PMID27035812 show ga
  • Humans circulate quadrillions of exosomes at all times. Exosomes are a class of extracellular vesicles released by all cells, with a size range of 40-150 nm and a lipid bilayer membrane. Exosomes contain DNA, RNA, and proteins. Exosomes likely remove excess and/or unnecessary constituents from the cells, functioning like garbage bags, although their precise physiological role remains unknown. Additionally, exosomes may mediate specific cell-to-cell communication and activate signaling pathways in cells they fuse or interact with. Exosomes are detected in the tumor microenvironment, and emerging evidence suggests that they play a role in facilitating tumorigenesis by regulating angiogenesis, immunity, and metastasis. Circulating exosomes can be used as liquid biopsies and noninvasive biomarkers for early detection, diagnosis, and treatment of cancer patients.
  • |*Cell Communication [MESH]
  • |*Signal Transduction [MESH]
  • |Animals [MESH]
  • |Biomarkers, Tumor/*metabolism [MESH]
  • |Cell-Derived Microparticles [MESH]
  • |DNA, Neoplasm/metabolism [MESH]
  • |Exosomes/*metabolism/pathology [MESH]
  • |Humans [MESH]
  • |Neoplasms/diagnosis/*metabolism/pathology [MESH]


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