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The antipsychotic landscape: dopamine and beyond
#MMPMID29607005
Morrison PD
; Murray RM
Ther Adv Psychopharmacol
2018[Apr]; 8
(4
): 127-135
PMID29607005
show ga
Until recently, the actions of antipsychotic and pro-psychotic drugs have largely
been evaluated in the framework of neuronal doctrine - namely, that neurons
communicate by releasing transmitters, and that psychiatric disorders are caused
by neurotransmitter imbalances. Moreover, the majority of studies have focused on
single transmitter systems - neglecting the fact that in the nervous system,
different transmitter systems work in concert and impact on not only their
immediate receptors but also downstream pathways that shape structural
plasticity. In this review, we discuss the history of understanding the
antipsychotic and pro-psychotic actions of drugs, recent developments and future
perspectives.