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10.1016/j.ceb.2015.04.008 http://scihub22266oqcxt.onion/10.1016/j.ceb.2015.04.008 C4522345!4522345 !25938907     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25938907 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Cell+Biol 2015 ; 34 (ä): 39-45 Nephropedia Template TP {{tp|p=25938907 |t=2015. The Yin and Yang of R-loop biology |pdf=|usr=}}{{25938907 }} gab.com Text The Yin and Yang of R-loop biology JO: Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25938907 #FOAvip RNA performs diverse functions in cells, directing translation, modulating transcription and catalyzing enzymatic reactions. Remarkably RNA can also anneal to its genomic template co- or post-transcriptionally to generate an RNA-DNA hybrid and a displaced single-stranded DNA. These unusual nucleic acid structures are called R-loops. Studies in the last decades concentrated on the detrimental effects of R-loop formation, particularly on genome stability. In fact, R-loops are thought to play a role in several human diseases like cancer and neurodegenerative syndromes. But recent data has revealed that R-loops can also have a positive impact on cell processes, like regulating gene expression, chromosome structure and DNA repair. Here we summarize our current understanding of the formation and dissolution of R-loops, and discuss their negative and positive impact on genome structure and function. Twit Text FOAVip The Yin and Yang of R-loop biology ????Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25938907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25938907 #FOAvip English Wikipedia <ref>{{Cite pmid|25938907 }}</ref> The Yin and Yang of R-loop biology #MMPMID25938907 Costantino L ; Koshland D Curr Opin Cell Biol 2015[Jun]; 34 (ä): 39-45 PMID25938907 show ga RNA performs diverse functions in cells, directing translation, modulating transcription and catalyzing enzymatic reactions. Remarkably RNA can also anneal to its genomic template co- or post-transcriptionally to generate an RNA-DNA hybrid and a displaced single-stranded DNA. These unusual nucleic acid structures are called R-loops. Studies in the last decades concentrated on the detrimental effects of R-loop formation, particularly on genome stability. In fact, R-loops are thought to play a role in several human diseases like cancer and neurodegenerative syndromes. But recent data has revealed that R-loops can also have a positive impact on cell processes, like regulating gene expression, chromosome structure and DNA repair. Here we summarize our current understanding of the formation and dissolution of R-loops, and discuss their negative and positive impact on genome structure and function. |Animals [MESH] |DNA Repair [MESH] |DNA/chemistry/*genetics [MESH] |Genome [MESH] |Genomic Instability [MESH] |Humans [MESH]The Yin and Yang of R-loop biology (epmc).pdf DeepDyve Pubget Overpricing