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10.1016/j.critrevonc.2015.12.005 http://scihub22266oqcxt.onion/10.1016/j.critrevonc.2015.12.005 C5853106!5853106 !26775730     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26775730 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26775730 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Crit+Rev+Oncol+Hematol 2016 ; 99 (ä): 141-9 Nephropedia Template TP {{tp|p=26775730 |t=2016. The Wnt signaling pathway in cancer |pdf=|usr=}}{{26775730 }} gab.com Text The Wnt signaling pathway in cancer JO: Crit Rev Oncol Hematol http://www.kidney.de/pget.php?&tw=1&pmid=26775730 #FOAvip The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the behavior of Cancer Stem Cells (CSCs). CSCs are considered by most to be responsible for establishment of the tumor and also for disease relapse, as they possess inherent drug-resistance properties. The development of new therapeutic compounds targeting the Wnt signaling pathway promises new hope to eliminate CSCs and achieve cancer eradication. However, a major challenge resides in developing a strategy efficient enough to target the dysregulated Wnt pathway in CSCs, while being safe enough to not damage the normal somatic stem cell population required for tissue homeostasis and repair. Here we review recent therapeutic approaches to target the Wnt pathway and their clinical applications. Twit Text FOAVip The Wnt signaling pathway in cancer ????Crit Rev Oncol Hematol http://www.kidney.de/pget.php?&tw=1&pmid=26775730 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26775730 #FOAvip English Wikipedia <ref>{{Cite pmid|26775730 }}</ref> The Wnt signaling pathway in cancer #MMPMID26775730 Duchartre Y ; Kim YM ; Kahn M Crit Rev Oncol Hematol 2016[Mar]; 99 (ä): 141-9 PMID26775730 show ga The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the behavior of Cancer Stem Cells (CSCs). CSCs are considered by most to be responsible for establishment of the tumor and also for disease relapse, as they possess inherent drug-resistance properties. The development of new therapeutic compounds targeting the Wnt signaling pathway promises new hope to eliminate CSCs and achieve cancer eradication. However, a major challenge resides in developing a strategy efficient enough to target the dysregulated Wnt pathway in CSCs, while being safe enough to not damage the normal somatic stem cell population required for tissue homeostasis and repair. Here we review recent therapeutic approaches to target the Wnt pathway and their clinical applications. |Animals [MESH] |Antineoplastic Agents/*therapeutic use [MESH] |Humans [MESH] |Neoplasms/*drug therapy/*metabolism [MESH] |Neoplastic Stem Cells/*drug effects/metabolism [MESH]The Wnt signaling pathway in cancer (epmc).pdf DeepDyve Pubget Overpricing