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10.1111/bph.13422 http://scihub22266oqcxt.onion/10.1111/bph.13422 C4793921!4793921 !26750865     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26750865 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26750865 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Pharmacol 2016 ; 173 (6 ): 970-9 Nephropedia Template TP {{tp|p=26750865 |t=2016. The Warburg effect and drug resistance |pdf=|usr=}}{{26750865 }} gab.com Text The Warburg effect and drug resistance JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26750865 #FOAvip : The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently, studies have begun to reveal how the Warburg effect could influence drug efficacy and how our understanding of tumour energetics could be exploited to improve drug development. In particular, evidence is emerging demonstrating how better modelling of the tumour metabolic microenvironment could lead to a better prediction of drug efficacy and the identification of new combination strategies. This review will provide details of the current understanding of the complex interplay between glucose metabolism and pharmacology and discuss opportunities for utilizing the Warburg effect in future drug development. Twit Text FOAVip The Warburg effect and drug resistance ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26750865 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26750865 #FOAvip English Wikipedia <ref>{{Cite pmid|26750865 }}</ref> The Warburg effect and drug resistance #MMPMID26750865 Bhattacharya B ; Mohd Omar MF ; Soong R Br J Pharmacol 2016[Mar]; 173 (6 ): 970-9 PMID26750865 show ga : The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently, studies have begun to reveal how the Warburg effect could influence drug efficacy and how our understanding of tumour energetics could be exploited to improve drug development. In particular, evidence is emerging demonstrating how better modelling of the tumour metabolic microenvironment could lead to a better prediction of drug efficacy and the identification of new combination strategies. This review will provide details of the current understanding of the complex interplay between glucose metabolism and pharmacology and discuss opportunities for utilizing the Warburg effect in future drug development. |*Drug Resistance [MESH] |Animals [MESH] |Drug Evaluation, Preclinical [MESH] |Glucose/*metabolism [MESH] |Glycolysis [MESH] |Humans [MESH] |Neoplasms/*metabolism [MESH]The Warburg effect and drug resistance (epmc).pdf DeepDyve Pubget Overpricing