Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29602394
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Semin+Nephrol
2018 ; 38
(2
): 111-120
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Warburg Effect in Diabetic Kidney Disease
#MMPMID29602394
Zhang G
; Darshi M
; Sharma K
Semin Nephrol
2018[Mar]; 38
(2
): 111-120
PMID29602394
show ga
Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in
diabetic patients. Defining risk factors for DKD using a reductionist approach
has proven challenging. Integrative omics-based systems biology tools have shed
new insights in our understanding of DKD and have provided several key
breakthroughs for identifying novel predictive and diagnostic biomarkers. In this
review, we highlight the role of the Warburg effect in DKD and potential
regulating factors such as sphingomyelin, fumarate, and pyruvate kinase muscle
isozyme M2 in shifting glucose flux from complete oxidation in mitochondria to
the glycolytic pathway and its principal branches. With the development of highly
sensitive instruments and more advanced automatic bioinformatics tools, we
believe that omics analyses and imaging techniques will focus more on
singular-cell-level studies, which will allow in-depth understanding of DKD and
pave the path for personalized kidney precision medicine.
free
free
free
