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10.1016/j.ebiom.2017.05.017 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2017.05.017 C5478243!5478243 !28558959     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28558959 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28558959 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EBioMedicine 2017 ; 20 (ä): 109-119 Nephropedia Template TP {{tp|p=28558959 |t=2017. The Transcriptional Landscape of p53 Signalling Pathway |pdf=|usr=}}{{28558959 }} gab.com Text The Transcriptional Landscape of p53 Signalling Pathway JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=28558959 #FOAvip Although recent cancer genomics studies have identified a large number of genes that were mutated in human cancers, p53 remains as the most frequently mutated gene. To further elucidate the p53-signalling network, we performed transcriptome analysis on 24 tissues in p53(+/+) or p53(-/-) mice after whole-body X-ray irradiation. Here we found transactivation of a total of 3551 genes in one or more of the 24 tissues only in p53(+/+) mice, while 2576 genes were downregulated. p53 mRNA expression level in each tissue was significantly associated with the number of genes upregulated by irradiation. Annotation using TCGA (The Cancer Genome Atlas) database revealed that p53 negatively regulated mRNA expression of several cancer therapeutic targets or pathways such as BTK, SYK, and CTLA4 in breast cancer tissues. In addition, stomach exhibited the induction of Krt6, Krt16, and Krt17 as well as loricrin, an epidermal differentiation marker, after the X-ray irradiation only in p53(+/+) mice, implying a mechanism to protect damaged tissues by rapid induction of differentiation. Our comprehensive transcriptome analysis elucidated tissue specific roles of p53 and its signalling networks in DNA-damage response that will enhance our understanding of cancer biology. Twit Text FOAVip The Transcriptional Landscape of p53 Signalling Pathway ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=28558959 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28558959 #FOAvip English Wikipedia <ref>{{Cite pmid|28558959 }}</ref> The Transcriptional Landscape of p53 Signalling Pathway #MMPMID28558959 Tanikawa C ; Zhang YZ ; Yamamoto R ; Tsuda Y ; Tanaka M ; Funauchi Y ; Mori J ; Imoto S ; Yamaguchi R ; Nakamura Y ; Miyano S ; Nakagawa H ; Matsuda K EBioMedicine 2017[Jun]; 20 (ä): 109-119 PMID28558959 show ga Although recent cancer genomics studies have identified a large number of genes that were mutated in human cancers, p53 remains as the most frequently mutated gene. To further elucidate the p53-signalling network, we performed transcriptome analysis on 24 tissues in p53(+/+) or p53(-/-) mice after whole-body X-ray irradiation. Here we found transactivation of a total of 3551 genes in one or more of the 24 tissues only in p53(+/+) mice, while 2576 genes were downregulated. p53 mRNA expression level in each tissue was significantly associated with the number of genes upregulated by irradiation. Annotation using TCGA (The Cancer Genome Atlas) database revealed that p53 negatively regulated mRNA expression of several cancer therapeutic targets or pathways such as BTK, SYK, and CTLA4 in breast cancer tissues. In addition, stomach exhibited the induction of Krt6, Krt16, and Krt17 as well as loricrin, an epidermal differentiation marker, after the X-ray irradiation only in p53(+/+) mice, implying a mechanism to protect damaged tissues by rapid induction of differentiation. Our comprehensive transcriptome analysis elucidated tissue specific roles of p53 and its signalling networks in DNA-damage response that will enhance our understanding of cancer biology. |*Gene Expression Regulation [MESH] |*Signal Transduction [MESH] |*Transcription, Genetic [MESH] |Animals [MESH] |Cell Transformation, Neoplastic/genetics/metabolism [MESH] |Computational Biology [MESH] |DNA Damage [MESH] |Gene Expression Profiling [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Mice [MESH] |Mice, Knockout [MESH] |RNA Splicing [MESH] |Transcriptome [MESH]The Transcriptional Landscape of p53 Signalling Pathway (epmc).pdf DeepDyve Pubget Overpricing