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2016 ; 26
(9
): 493-511
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The Tohoku Medical Megabank Project: Design and Mission
#MMPMID27374138
Kuriyama S
; Yaegashi N
; Nagami F
; Arai T
; Kawaguchi Y
; Osumi N
; Sakaida M
; Suzuki Y
; Nakayama K
; Hashizume H
; Tamiya G
; Kawame H
; Suzuki K
; Hozawa A
; Nakaya N
; Kikuya M
; Metoki H
; Tsuji I
; Fuse N
; Kiyomoto H
; Sugawara J
; Tsuboi A
; Egawa S
; Ito K
; Chida K
; Ishii T
; Tomita H
; Taki Y
; Minegishi N
; Ishii N
; Yasuda J
; Igarashi K
; Shimizu R
; Nagasaki M
; Koshiba S
; Kinoshita K
; Ogishima S
; Takai-Igarashi T
; Tominaga T
; Tanabe O
; Ohuchi N
; Shimosegawa T
; Kure S
; Tanaka H
; Ito S
; Hitomi J
; Tanno K
; Nakamura M
; Ogasawara K
; Kobayashi S
; Sakata K
; Satoh M
; Shimizu A
; Sasaki M
; Endo R
; Sobue K
; Tohoku Medical Megabank Project Study Group T
; Yamamoto M
J Epidemiol
2016[Sep]; 26
(9
): 493-511
PMID27374138
show ga
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011
gave rise to devastating damage on the Pacific coast of the Tohoku region. The
Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku
University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical
University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to
realize creative reconstruction and to solve medical problems in the aftermath of
this disaster. We started two prospective cohort studies in Miyagi and Iwate
Prefectures: a population-based adult cohort study, the TMM Community-Based
Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and
a birth and three-generation cohort study, the TMM Birth and Three-Generation
Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants,
including fetuses and their parents, siblings, grandparents, and extended family
members. The TMM CommCohort Study will recruit participants from 2013 to 2016 and
follow them for at least 5 years. The TMM BirThree Cohort Study will recruit
participants from 2013 to 2017 and follow them for at least 4 years. For
children, the ToMMo Child Health Study, which adopted a cross-sectional design,
was also started in November 2012 in Miyagi Prefecture. An integrated biobank
will be constructed based on the two prospective cohort studies, and ToMMo and
IMM will investigate the chronic medical impacts of the GEJE. The integrated
biobank of TMM consists of health and clinical information, biospecimens, and
genome and omics data. The biobank aims to establish a firm basis for
personalized healthcare and medicine, mainly for diseases aggravated by the GEJE
in the two prefectures. Biospecimens and related information in the biobank will
be distributed to the research community. TMM itself will also undertake genomic
and omics research. The aims of the genomic studies are: 1) to construct an
integrated biobank; 2) to return genomic research results to the participants of
the cohort studies, which will lead to the implementation of personalized
healthcare and medicine in the affected areas in the near future; and 3) to
contribute the development of personalized healthcare and medicine worldwide.
Through the activities of TMM, we will clarify how to approach prolonged
healthcare problems in areas damaged by large-scale disasters and how useful
genomic information is for disease prevention.
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