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2016 ; 11
(ä): 9-15
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The TNBS-induced colitis animal model: An overview
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Antoniou E
; Margonis GA
; Angelou A
; Pikouli A
; Argiri P
; Karavokyros I
; Papalois A
; Pikoulis E
Ann Med Surg (Lond)
2016[Nov]; 11
(ä): 9-15
PMID27656280
show ga
BACKGROUND: Despite recent advances the pathogenesis of Crohn's disease remains
incompletely understood. A variety of animal models have been utilized in an
effort to provide further insights and develop more therapeutic options. In order
to simulate, to an extent, the pathogenesis and the clinical course of the
disease, TNBS induced colitis is often used. Various approaches for inducing TNBS
-colitis have been described in the literature. METHODS/RESULTS: In this review,
we sought to present the animal model of TNBS induced colitis and outline the
pathogenesis, pathophysiology, clinical course and pathological characteristics
of the model. Furthermore, we describe the differences among those protocols
regarding types of animals and colitis induction. DATA SOURCES: The MEDLINE
database was thoroughly searched using the keywords: TNBS, colitis, Crohn's
disease, animal model. Two investigators independently reviewed the abstracts and
appropriate articles were included in this review. Additional articles were
gathered and evaluated. CONCLUSION: The aim of this study was to thoroughly
present an updated review of the TNBS-induced colitis protocols that are
implemented by researchers.
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