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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Mol+Biol
2016 ; 428
(10 Pt A
): 1986-2000
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The Structure Inventory of the Nuclear Pore Complex
#MMPMID27016207
Schwartz TU
J Mol Biol
2016[May]; 428
(10 Pt A
): 1986-2000
PMID27016207
show ga
The nuclear pore complex (NPC) is the principal gateway for molecular exchange
between nucleus and cytoplasm across the nuclear envelope. Due to its sheer size
of estimated 50-112MDa and its complex buildup from about 500-1000 individual
proteins, it is a difficult object to study for structural biologists. Here, I
review the extensive ensemble of high-resolution structures of the building
blocks of the NPC. Concurrent with the increase in size and complexity, these
latest, large structures and assemblies can now be used as the basis for hybrid
approaches, primarily in combination with cryo-electron microscopic analysis,
generating the first structure-based assembly models of the NPC. Going forward,
the structures will be critically important for a detailed analysis of the NPC,
including function, evolution, and assembly.