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10.1371/journal.pgen.1006340 http://scihub22266oqcxt.onion/10.1371/journal.pgen.1006340 C5100956!5100956 !27824859     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27824859 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27824859 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Genet 2016 ; 12 (11 ): e1006340 Nephropedia Template TP {{tp|p=27824859 |t=2016. The Strength of Selection against Neanderthal Introgression |pdf=|usr=}}{{27824859 }} gab.com Text The Strength of Selection against Neanderthal Introgression JO: PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=27824859 #FOAvip Hybridization between humans and Neanderthals has resulted in a low level of Neanderthal ancestry scattered across the genomes of many modern-day humans. After hybridization, on average, selection appears to have removed Neanderthal alleles from the human population. Quantifying the strength and causes of this selection against Neanderthal ancestry is key to understanding our relationship to Neanderthals and, more broadly, how populations remain distinct after secondary contact. Here, we develop a novel method for estimating the genome-wide average strength of selection and the density of selected sites using estimates of Neanderthal allele frequency along the genomes of modern-day humans. We confirm that East Asians had somewhat higher initial levels of Neanderthal ancestry than Europeans even after accounting for selection. We find that the bulk of purifying selection against Neanderthal ancestry is best understood as acting on many weakly deleterious alleles. We propose that the majority of these alleles were effectively neutral-and segregating at high frequency-in Neanderthals, but became selected against after entering human populations of much larger effective size. While individually of small effect, these alleles potentially imposed a heavy genetic load on the early-generation human-Neanderthal hybrids. This work suggests that differences in effective population size may play a far more important role in shaping levels of introgression than previously thought. Twit Text FOAVip The Strength of Selection against Neanderthal Introgression ????PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=27824859 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27824859 #FOAvip English Wikipedia <ref>{{Cite pmid|27824859 }}</ref> The Strength of Selection against Neanderthal Introgression #MMPMID27824859 Juric I ; Aeschbacher S ; Coop G PLoS Genet 2016[Nov]; 12 (11 ): e1006340 PMID27824859 show ga Hybridization between humans and Neanderthals has resulted in a low level of Neanderthal ancestry scattered across the genomes of many modern-day humans. After hybridization, on average, selection appears to have removed Neanderthal alleles from the human population. Quantifying the strength and causes of this selection against Neanderthal ancestry is key to understanding our relationship to Neanderthals and, more broadly, how populations remain distinct after secondary contact. Here, we develop a novel method for estimating the genome-wide average strength of selection and the density of selected sites using estimates of Neanderthal allele frequency along the genomes of modern-day humans. We confirm that East Asians had somewhat higher initial levels of Neanderthal ancestry than Europeans even after accounting for selection. We find that the bulk of purifying selection against Neanderthal ancestry is best understood as acting on many weakly deleterious alleles. We propose that the majority of these alleles were effectively neutral-and segregating at high frequency-in Neanderthals, but became selected against after entering human populations of much larger effective size. While individually of small effect, these alleles potentially imposed a heavy genetic load on the early-generation human-Neanderthal hybrids. This work suggests that differences in effective population size may play a far more important role in shaping levels of introgression than previously thought. |*Genetics, Population [MESH] |*Genome, Human [MESH] |Alleles [MESH] |Animals [MESH] |Asian People/genetics [MESH] |Gene Frequency [MESH] |Haplotypes [MESH] |Humans [MESH] |Hybridization, Genetic [MESH] |Neanderthals/*genetics [MESH] |Phylogeny [MESH] |Polymorphism, Single Nucleotide [MESH] |Selection, Genetic/*genetics [MESH]The Strength of Selection against Neanderthal Introgression (epmc).pdf DeepDyve Pubget Overpricing