Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27812219
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27812219
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+Pathog
2016 ; 12
(11
): e1005819
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Strange Lifestyle of Multipartite Viruses
#MMPMID27812219
Sicard A
; Michalakis Y
; Gutiérrez S
; Blanc S
PLoS Pathog
2016[Nov]; 12
(11
): e1005819
PMID27812219
show ga
Multipartite viruses have one of the most puzzling genetic organizations found in
living organisms. These viruses have several genome segments, each containing
only a part of the genetic information, and each individually encapsidated into a
separate virus particle. While countless studies on molecular and cellular
mechanisms of the infection cycle of multipartite viruses are available, just as
for other virus types, very seldom is their lifestyle questioned at the viral
system level. Moreover, the rare available "system" studies are purely
theoretical, and their predictions on the putative benefit/cost balance of this
peculiar genetic organization have not received experimental support. In light of
ongoing progresses in general virology, we here challenge the current hypotheses
explaining the evolutionary success of multipartite viruses and emphasize their
shortcomings. We also discuss alternative ideas and research avenues to be
explored in the future in order to solve the long-standing mystery of how viral
systems composed of interdependent but physically separated information units can
actually be functional.
free
free
free
