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10.15252/embj.201489642 http://scihub22266oqcxt.onion/10.15252/embj.201489642 C4388601!4388601 !25712476     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25712476 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2015 ; 34 (7 ): 940-54 Nephropedia Template TP {{tp|p=25712476 |t=2015. The Spectrin cytoskeleton regulates the Hippo signalling pathway |pdf=|usr=}}{{25712476 }} gab.com Text The Spectrin cytoskeleton regulates the Hippo signalling pathway JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25712476 #FOAvip The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains poorly understood. Here, we show that the Spectrin cytoskeleton controls Hippo signalling. In the developing Drosophila wing and eye, loss of apical Spectrins (alpha/beta-heavy dimers) produces tissue overgrowth and mis-regulation of Hippo target genes, similar to loss of Crumbs (Crb) or the FERM-domain protein Expanded (Ex). Apical beta-heavy Spectrin binds to Ex and co-localises with it at the apical membrane to antagonise Yki activity. Interestingly, in both the ovarian follicular epithelium and intestinal epithelium of Drosophila, apical Spectrins and Crb are dispensable for repression of Yki, while basolateral Spectrins (alpha/beta dimers) are essential. Finally, the Spectrin cytoskeleton is required to regulate the localisation of the Hippo pathway effector YAP in response to cell density human epithelial cells. Our findings identify both apical and basolateral Spectrins as regulators of Hippo signalling and suggest Spectrins as potential mechanosensors. Twit Text FOAVip The Spectrin cytoskeleton regulates the Hippo signalling pathway ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25712476 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25712476 #FOAvip English Wikipedia <ref>{{Cite pmid|25712476 }}</ref> The Spectrin cytoskeleton regulates the Hippo signalling pathway #MMPMID25712476 Fletcher GC ; Elbediwy A ; Khanal I ; Ribeiro PS ; Tapon N ; Thompson BJ EMBO J 2015[Apr]; 34 (7 ): 940-54 PMID25712476 show ga The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains poorly understood. Here, we show that the Spectrin cytoskeleton controls Hippo signalling. In the developing Drosophila wing and eye, loss of apical Spectrins (alpha/beta-heavy dimers) produces tissue overgrowth and mis-regulation of Hippo target genes, similar to loss of Crumbs (Crb) or the FERM-domain protein Expanded (Ex). Apical beta-heavy Spectrin binds to Ex and co-localises with it at the apical membrane to antagonise Yki activity. Interestingly, in both the ovarian follicular epithelium and intestinal epithelium of Drosophila, apical Spectrins and Crb are dispensable for repression of Yki, while basolateral Spectrins (alpha/beta dimers) are essential. Finally, the Spectrin cytoskeleton is required to regulate the localisation of the Hippo pathway effector YAP in response to cell density human epithelial cells. Our findings identify both apical and basolateral Spectrins as regulators of Hippo signalling and suggest Spectrins as potential mechanosensors. |Animals [MESH] |Cell Line [MESH] |Cytoskeleton/genetics/*metabolism [MESH] |Drosophila Proteins/genetics/*metabolism [MESH] |Drosophila melanogaster [MESH] |Female [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/genetics/*metabolism [MESH] |Mechanotransduction, Cellular/*physiology [MESH] |Membrane Proteins/genetics/metabolism [MESH] |Nuclear Proteins/genetics/metabolism [MESH] |Ovarian Follicle/cytology/*metabolism [MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH] |Spectrin/genetics/*metabolism [MESH] |Trans-Activators/genetics/metabolism [MESH]The Spectrin cytoskeleton regulates the Hippo signalling pathway (epmc).pdf DeepDyve Pubget Overpricing