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2015 ; 114
(ä): 241-65
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The Sound of Silence: Signaling by Apoptotic Cells
#MMPMID26431570
Fogarty CE
; Bergmann A
Curr Top Dev Biol
2015[]; 114
(ä): 241-65
PMID26431570
show ga
Apoptosis is a carefully choreographed process of cellular self-destruction in
the absence of inflammation. During the death process, apoptotic cells actively
communicate with their environment, signaling to both their immediate neighbors
as well as distant sentinels. Some of these signals direct the anti-inflammatory
immune response, instructing specific subsets of phagocytes to participate in the
limited and careful clearance of dying cellular debris. These immunomodulatory
signals can also regulate the activation state of the engulfing phagocytes. Other
signals derived from apoptotic cells contribute to tissue growth control with the
common goal of maintaining tissue integrity. Derangements in these growth control
signals during prolonged apoptosis can lead to excessive cell loss or
proliferation. Here, we highlight some of the most intriguing signals produced by
apoptotic cells during the course of normal development as well as during
physiological disturbances such as atherosclerosis and cancer.
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