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2015 ; 5
(2
): 172-86
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The Scanning TMR Microscope for Biosensor Applications
#MMPMID25849347
Vyas KN
; Love DM
; Ionescu A
; Llandro J
; Kollu P
; Mitrelias T
; Holmes S
; Barnes CH
Biosensors (Basel)
2015[Apr]; 5
(2
): 172-86
PMID25849347
show ga
We present a novel tunnel magnetoresistance (TMR) scanning microscope set-up
capable of quantitatively imaging the magnetic stray field patterns of
micron-sized elements in 3D. By incorporating an Anderson loop measurement
circuit for impedance matching, we are able to detect magnetoresistance changes
of as little as 0.006%/Oe. By 3D rastering a mounted TMR sensor over our magnetic
barcodes, we are able to characterize the complex domain structures by displaying
the real component, the amplitude and the phase of the sensor's impedance. The
modular design, incorporating a TMR sensor with an optical microscope, renders
this set-up a versatile platform for studying and imaging immobilised magnetic
carriers and barcodes currently employed in biosensor platforms, magnetotactic
bacteria and other complex magnetic domain structures of micron-sized entities.
The quantitative nature of the instrument and its ability to produce vector maps
of magnetic stray fields has the potential to provide significant advantages over
other commonly used scanning magnetometry techniques.