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2016 ; 45
(3
): 543-56
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The Role of the Microbiome in Gastrointestinal Cancer
#MMPMID27546848
Wroblewski LE
; Peek RM Jr
; Coburn LA
Gastroenterol Clin North Am
2016[Sep]; 45
(3
): 543-56
PMID27546848
show ga
Humans are host to complex microbial communities previously termed normal flora
and largely overlooked. However, resident microbes contribute to both health and
disease. Investigators are beginning to define microbes that contribute to the
development of gastrointestinal malignancies and the mechanisms by which this
occurs. Resident microbes can induce inflammation, leading to cell proliferation
and altered stem cell dynamics, which can lead to alterations in DNA integrity
and immune regulation and promote carcinogenesis. Studies in human patients and
rodent models of cancer have identified alterations in the microbiota of the
stomach, esophagus, and colon that increase the risk for malignancy.
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