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10.1371/journal.pone.0153692 http://scihub22266oqcxt.onion/10.1371/journal.pone.0153692 C4835055!4835055 !27088720     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27088720 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27088720 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2016 ; 11 (4 ): e0153692 Nephropedia Template TP {{tp|p=27088720 |t=2016. The Role of Oxygen in Avascular Tumor Growth |pdf=|usr=}}{{27088720 }} gab.com Text The Role of Oxygen in Avascular Tumor Growth JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27088720 #FOAvip The oxygen status of a tumor has significant clinical implications for treatment prognosis, with well-oxygenated subvolumes responding markedly better to radiotherapy than poorly supplied regions. Oxygen is essential for tumor growth, yet estimation of local oxygen distribution can be difficult to ascertain in situ, due to chaotic patterns of vasculature. It is possible to avoid this confounding influence by using avascular tumor models, such as tumor spheroids, a much better approximation of realistic tumor dynamics than monolayers, where oxygen supply can be described by diffusion alone. Similar to in situ tumours, spheroids exhibit an approximately sigmoidal growth curve, often approximated and fitted by logistic and Gompertzian sigmoid functions. These describe the basic rate of growth well, but do not offer an explicitly mechanistic explanation. This work examines the oxygen dynamics of spheroids and demonstrates that this growth can be derived mechanistically with cellular doubling time and oxygen consumption rate (OCR) being key parameters. The model is fitted to growth curves for a range of cell lines and derived values of OCR are validated using clinical measurement. Finally, we illustrate how changes in OCR due to gemcitabine treatment can be directly inferred using this model. Twit Text FOAVip The Role of Oxygen in Avascular Tumor Growth ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27088720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27088720 #FOAvip English Wikipedia <ref>{{Cite pmid|27088720 }}</ref> The Role of Oxygen in Avascular Tumor Growth #MMPMID27088720 Grimes DR ; Kannan P ; McIntyre A ; Kavanagh A ; Siddiky A ; Wigfield S ; Harris A ; Partridge M PLoS One 2016[]; 11 (4 ): e0153692 PMID27088720 show ga The oxygen status of a tumor has significant clinical implications for treatment prognosis, with well-oxygenated subvolumes responding markedly better to radiotherapy than poorly supplied regions. Oxygen is essential for tumor growth, yet estimation of local oxygen distribution can be difficult to ascertain in situ, due to chaotic patterns of vasculature. It is possible to avoid this confounding influence by using avascular tumor models, such as tumor spheroids, a much better approximation of realistic tumor dynamics than monolayers, where oxygen supply can be described by diffusion alone. Similar to in situ tumours, spheroids exhibit an approximately sigmoidal growth curve, often approximated and fitted by logistic and Gompertzian sigmoid functions. These describe the basic rate of growth well, but do not offer an explicitly mechanistic explanation. This work examines the oxygen dynamics of spheroids and demonstrates that this growth can be derived mechanistically with cellular doubling time and oxygen consumption rate (OCR) being key parameters. The model is fitted to growth curves for a range of cell lines and derived values of OCR are validated using clinical measurement. Finally, we illustrate how changes in OCR due to gemcitabine treatment can be directly inferred using this model. |*Models, Theoretical [MESH] |Antimetabolites, Antineoplastic/pharmacology [MESH] |Deoxycytidine/*analogs & derivatives/pharmacology [MESH] |Gemcitabine [MESH] |Humans [MESH] |Neoplasms/*drug therapy/*pathology [MESH] |Oxygen Consumption/*drug effects [MESH] |Oxygen/*metabolism [MESH]The Role of Oxygen in Avascular Tumor Growth (epmc).pdf DeepDyve Pubget Overpricing