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10.1177/0963689717753378 http://scihub22266oqcxt.onion/10.1177/0963689717753378 C6038035!6038035 !29766738     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29766738 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Transplant 2018 ; 27 (3 ): 364-378 Nephropedia Template TP {{tp|p=29766738 |t=2018. The Role of Gene Editing in Neurodegenerative Diseases |pdf=|usr=}}{{29766738 }} gab.com Text The Role of Gene Editing in Neurodegenerative Diseases JO: Cell Transplant http://www.kidney.de/pget.php?&tw=1&pmid=29766738 #FOAvip Neurodegenerative diseases (NDs), at least including Alzheimer's, Huntington's, and Parkinson's diseases, have become the most dreaded maladies because there are no precise diagnostic tools or definite treatments for these debilitating diseases. The increased prevalence and a substantial impact on the social-economic and medical care of NDs propel governments to develop policies to counteract the impact. Although the etiologies of NDs are still unknown, growing evidence suggests that genetic, cellular, and circuit alternations may cause the generation of abnormal misfolded proteins, which uncontrolledly accumulate to damage and eventually overwhelm the protein-disposal mechanisms of these neurons, leading to a common pathological feature of NDs. If the functions and the connectivity can be restored, alterations and accumulated damages may improve. The gene-editing tools including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats-associated nucleases (CRISPR/CAS) have emerged as a novel tool not only for generating specific ND animal models for interrogating the mechanisms and screening potential drugs against NDs but also for the editing sequence-specific genes to help patients with NDs to regain function and connectivity. This review introduces the clinical manifestations of three distinct NDs and the applications of the gene-editing technology on these debilitating diseases. Twit Text FOAVip The Role of Gene Editing in Neurodegenerative Diseases ????Cell Transplant http://www.kidney.de/pget.php?&tw=1&pmid=29766738 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29766738 #FOAvip English Wikipedia <ref>{{Cite pmid|29766738 }}</ref> The Role of Gene Editing in Neurodegenerative Diseases #MMPMID29766738 Fan HC ; Chi CS ; Lee YJ ; Tsai JD ; Lin SZ ; Harn HJ Cell Transplant 2018[Mar]; 27 (3 ): 364-378 PMID29766738 show ga Neurodegenerative diseases (NDs), at least including Alzheimer's, Huntington's, and Parkinson's diseases, have become the most dreaded maladies because there are no precise diagnostic tools or definite treatments for these debilitating diseases. The increased prevalence and a substantial impact on the social-economic and medical care of NDs propel governments to develop policies to counteract the impact. Although the etiologies of NDs are still unknown, growing evidence suggests that genetic, cellular, and circuit alternations may cause the generation of abnormal misfolded proteins, which uncontrolledly accumulate to damage and eventually overwhelm the protein-disposal mechanisms of these neurons, leading to a common pathological feature of NDs. If the functions and the connectivity can be restored, alterations and accumulated damages may improve. The gene-editing tools including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats-associated nucleases (CRISPR/CAS) have emerged as a novel tool not only for generating specific ND animal models for interrogating the mechanisms and screening potential drugs against NDs but also for the editing sequence-specific genes to help patients with NDs to regain function and connectivity. This review introduces the clinical manifestations of three distinct NDs and the applications of the gene-editing technology on these debilitating diseases. |*Gene Editing [MESH] |Clustered Regularly Interspaced Short Palindromic Repeats/genetics [MESH] |Humans [MESH] |Neurodegenerative Diseases/*genetics [MESH] |Parkinson Disease/genetics [MESH]The Role of Gene Editing in Neurodegenerative Diseases (epmc).pdf DeepDyve Pubget Overpricing