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2016 ; 17
(4
): 565
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The Role of Galectin-3 in the Kidneys
#MMPMID27089335
Chen SC
; Kuo PL
Int J Mol Sci
2016[Apr]; 17
(4
): 565
PMID27089335
show ga
Galectin-3 is a 32- to 35-kDa member of the galectin family of
b-galactoside-binding lectins, which is characterized by a carbohydrate
recognition domain. Through its carbohydrate-binding function, it regulates cell
growth, differentiation, and inflammation. It also plays a complex,
context-dependent role in the kidneys. During development, it promotes
nephrogenesis and is strongly expressed in the ureteric bud and its derivatives.
An increase in the concentration of galectin-3 has been reported to be associated
with fibrosis of the kidneys. Elevated levels of plasma galectin-3 are also
associated with increased risks of rapid renal function decline, incident chronic
kidney disease, and progressive renal impairment, and also with cardiovascular
end points, infection, and all-cause mortality in patients with renal function
impairment. This review discusses a general survey on galectin-3 expressions in
nephrogenesis, kidney injury animal models, clinical renal diseases, renal
transplantation and the potential role of galectin-3 for treatment in kidney
disease.
|Animals
[MESH]
|Galectin 3/analysis/blood/*metabolism
[MESH]
|Glycation End Products, Advanced/metabolism
[MESH]
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