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2015 ; 16
(11
): 26629-43
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The Role of Autophagy in Hepatocellular Carcinoma
#MMPMID26561802
Lee YJ
; Jang BK
Int J Mol Sci
2015[Nov]; 16
(11
): 26629-43
PMID26561802
show ga
Autophagy is a catabolic process involved in cellular homeostasis under basal and
stressed conditions. Autophagy is crucial for normal liver physiology and the
pathogenesis of liver diseases. During the last decade, the function of autophagy
in hepatocellular carcinoma (HCC) has been evaluated extensively. Currently,
autophagy is thought to play a dual role in HCC, i.e., autophagy is involved in
tumorigenesis and tumor suppression. Recent investigations of autophagy have
suggested that autophagy biomarkers can facilitate HCC prognosis and the
establishment of therapeutic approaches. In this review, we briefly summarize the
current understanding of autophagy and discuss recent evidence for its role in
HCC.
|*Gene Expression Regulation, Neoplastic
[MESH]
|AMP-Activated Protein Kinases/genetics/metabolism
[MESH]