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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Immunol
2018 ; 9
(ä): 217
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The Role of Astrocytes in Multiple Sclerosis
#MMPMID29515568
Ponath G
; Park C
; Pitt D
Front Immunol
2018[]; 9
(ä): 217
PMID29515568
show ga
The role traditionally assigned to astrocytes in the pathogenesis of multiple
sclerosis (MS) lesions has been the formation of the glial scar once inflammation
has subsided. Astrocytes are now recognized to be early and highly active players
during lesion formation and key for providing peripheral immune cells access to
the central nervous system. Here, we review the role of astrocytes in the
formation and evolution of MS lesions, including the recently described
functional polarization of astrocytes, discuss prototypical pathways for
astrocyte activation, and summarize mechanisms by which MS treatments affect
astrocyte function.