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10.3390/cells5010012

http://scihub22266oqcxt.onion/10.3390/cells5010012
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suck abstract from ncbi


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pmid26999213
      Cells 2016 ; 5 (1 ): ä
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  • The Regulation of NF-?B Subunits by Phosphorylation #MMPMID26999213
  • Christian F ; Smith EL ; Carmody RJ
  • Cells 2016[Mar]; 5 (1 ): ä PMID26999213 show ga
  • The NF-?B transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-?B regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-?B plays in key physiological processes makes it an important factor in determining health and disease. The importance of NF-?B in tissue homeostasis and immunity has frustrated therapeutic approaches aimed at inhibiting NF-?B activation. However, significant research efforts have revealed the crucial contribution of NF-?B phosphorylation to controlling NF-?B directed transactivation. Importantly, NF-?B phosphorylation controls transcription in a gene-specific manner, offering new opportunities to selectively target NF-?B for therapeutic benefit. This review will focus on the phosphorylation of the NF-?B subunits and the impact on NF-?B function.
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