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10.1182/blood-2015-09-668962 http://scihub22266oqcxt.onion/10.1182/blood-2015-09-668962 C4683328!4683328 !26679542     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26679542 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood 2015 ; 126 (25 ): 2658-9 Nephropedia Template TP {{tp|p=26679542 |t=2015. The Rap1-RIAM pathway prefers ?2 integrins |pdf=|usr=}}{{26679542 }} gab.com Text The Rap1-RIAM pathway prefers 2 integrins JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=26679542 #FOAvip In vitro studies strongly implicate the talin-binding Ras-related protein 1 (Rap1) effector, Rap1-guanosine triphosphate?interacting adapter molecule (RIAM), in integrin activation. Yet, the RIAM knockout mouse is viable and fertile and exhibits no platelet adhesion or aggregation defects, casting doubt on the in vivo role of RIAM. In this issue of Blood, Su et al and Klapproth et al now show that RIAM is required for ?2 integrin?dependent leukocyte adhesion and trafficking in vitro and in vivo, but apparently not for all Rap- and talin-meditated activation of ?1 and ?3 integrins. Twit Text FOAVip The Rap1-RIAM pathway prefers 2 integrins ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=26679542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26679542 #FOAvip English Wikipedia <ref>{{Cite pmid|26679542 }}</ref> The Rap1-RIAM pathway prefers ?2 integrins #MMPMID26679542 Calderwood DA Blood 2015[Dec]; 126 (25 ): 2658-9 PMID26679542 show ga In vitro studies strongly implicate the talin-binding Ras-related protein 1 (Rap1) effector, Rap1-guanosine triphosphate?interacting adapter molecule (RIAM), in integrin activation. Yet, the RIAM knockout mouse is viable and fertile and exhibits no platelet adhesion or aggregation defects, casting doubt on the in vivo role of RIAM. In this issue of Blood, Su et al and Klapproth et al now show that RIAM is required for ?2 integrin?dependent leukocyte adhesion and trafficking in vitro and in vivo, but apparently not for all Rap- and talin-meditated activation of ?1 and ?3 integrins. |Adaptor Proteins, Signal Transducing/*immunology/*metabolism [MESH] |Animals [MESH] |B-Lymphocytes/*immunology [MESH] |CD18 Antigens/*metabolism [MESH] |Chemotaxis, Leukocyte/*immunology/*physiology [MESH] |Leukocytes/*metabolism [MESH] |Membrane Proteins/*immunology/*metabolism [MESH]The Rap1-RIAM pathway prefers ?2 integrins (epmc).pdf DeepDyve Pubget Overpricing