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10.1016/j.cmet.2016.07.024 http://scihub22266oqcxt.onion/10.1016/j.cmet.2016.07.024 C5031559!5031559!27546460     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27546460.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Metab 2016 ; 24 (3): 462-73 Nephropedia Template TP {{tp|p=27546460|t=2016. The Pentose Phosphate Pathway Regulates the Circadian Clock |pdf=|usr=}}{{27546460}} gab.com Text The Pentose Phosphate Pathway Regulates the Circadian Clock JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27546460 #FOAvip The circadian clock is a ubiquitous timekeeping system that organizes the behavior and physiology of organisms over the day and night. Current models rely on transcriptional networks that coordinate circadian gene expression of thousands of transcripts. However, recent studies have uncovered phylogenetically conserved redox rhythms that can occur independently of transcriptional cycles. Here we identify the pentose phosphate pathway (PPP), a critical source of the redox cofactor NADPH, as an important regulator of redox and transcriptional oscillations. Our results show that genetic and pharmacological inhibition of the PPP prolongs the period of circadian rhythms in human cells, mouse tissues, and fruit flies. These metabolic manipulations also cause a remodeling of circadian gene expression programs that involves the circadian transcription factors BMAL1 and CLOCK, and the redox-sensitive transcription factor NRF2. Thus, the PPP regulates circadian rhythms via NADPH metabolism, suggesting a pivotal role for NADPH availability in circadian timekeeping. Twit Text FOAVip The Pentose Phosphate Pathway Regulates the Circadian Clock ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=27546460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27546460 #FOAvip English Wikipedia <ref>{{Cite pmid|27546460}}</ref> The Pentose Phosphate Pathway Regulates the Circadian Clock #MMPMID27546460 Rey G; Valekunja U; Feeney K; Wulund L; Milev N; Stangherlin A; Ansel-Bollepalli L; Velagapudi V; O?Neill J; Reddy A Cell Metab 2016[Sep]; 24 (3): 462-73 PMID27546460show ga The circadian clock is a ubiquitous timekeeping system that organizes the behavior and physiology of organisms over the day and night. Current models rely on transcriptional networks that coordinate circadian gene expression of thousands of transcripts. However, recent studies have uncovered phylogenetically conserved redox rhythms that can occur independently of transcriptional cycles. Here we identify the pentose phosphate pathway (PPP), a critical source of the redox cofactor NADPH, as an important regulator of redox and transcriptional oscillations. Our results show that genetic and pharmacological inhibition of the PPP prolongs the period of circadian rhythms in human cells, mouse tissues, and fruit flies. These metabolic manipulations also cause a remodeling of circadian gene expression programs that involves the circadian transcription factors BMAL1 and CLOCK, and the redox-sensitive transcription factor NRF2. Thus, the PPP regulates circadian rhythms via NADPH metabolism, suggesting a pivotal role for NADPH availability in circadian timekeeping. äThe Pentose Phosphate Pathway Regulates the Circadian Clock (epmc).pdf DeepDyve Pubget Overpricing