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2017 ; 8
(ä): 13
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The Pancreatic Islet Regulome Browser
#MMPMID28261261
Mularoni L
; Ramos-Rodríguez M
; Pasquali L
Front Genet
2017[]; 8
(ä): 13
PMID28261261
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The pancreatic islet is a highly specialized tissue embedded in the exocrine
pancreas whose primary function is that of controlling glucose homeostasis. Thus,
understanding the transcriptional control of islet-cell may help to puzzle out
the pathogenesis of glucose metabolism disorders. Integrative computational
analyses of transcriptomic and epigenomic data allows predicting genomic
coordinates of putative regulatory elements across the genome and, decipher
tissue-specific functions of the non-coding genome. We herein present the Islet
Regulome Browser, a tool that allows fast access and exploration of pancreatic
islet epigenomic and transcriptomic data produced by different labs worldwide.
The Islet Regulome Browser is now accessible on the internet or may be installed
locally. It allows uploading custom tracks as well as providing interactive
access to a wealth of information including Genome-Wide Association Studies
(GWAS) variants, different classes of regulatory elements, together with enhancer
clusters, stretch-enhancers and transcription factor binding sites in pancreatic
progenitors and adult human pancreatic islets. Integration and visualization of
such data may allow a deeper understanding of the regulatory networks driving
tissue-specific transcription and guide the identification of regulatory
variants. We believe that such tool will facilitate the access to pancreatic
islet public genomic datasets providing a major boost to functional genomics
studies in glucose metabolism related traits including diabetes.
free
free
free
