Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27494162
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Crit+Rev+Biochem+Mol+Biol
2016 ; 51
(5
): 359-378
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The PI3K pathway in B cell metabolism
#MMPMID27494162
Jellusova J
; Rickert RC
Crit Rev Biochem Mol Biol
2016[Sep]; 51
(5
): 359-378
PMID27494162
show ga
B cell growth and proliferation is tightly regulated by signaling through the B
cell receptor and by other membrane bound receptors responding to different
cytokines. The PI3K signaling pathway has been shown to play a crucial role in B
cell activation, differentiation and survival. Activated B cells undergo
metabolic reprograming in response to changing energetic and biosynthetic
demands. B cells also need to be able to coordinate metabolic activity and
proliferation with nutrient availability. The PI3K signaling network has been
implicated in regulating nutrient acquisition, utilization and biosynthesis, thus
integrating receptor-mediated signaling with cell metabolism. In this review, we
discuss the current knowledge about metabolic changes induced in activated B
cells, strategies to adapt to metabolic stress and the role of PI3K signaling in
these processes.
free
free
free
