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2017 ; 102
(3
): 459-469
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The Nephrotoxicity of Vancomycin
#MMPMID28474732
Filippone EJ
; Kraft WK
; Farber JL
Clin Pharmacol Ther
2017[Sep]; 102
(3
): 459-469
PMID28474732
show ga
Vancomycin use is often associated with nephrotoxicity. It remains uncertain,
however, to what extent vancomycin is directly responsible, as numerous potential
risk factors for acute kidney injury frequently coexist. Herein, we critically
examine available data in adult patients pertinent to this question. We review
the pharmacokinetics/pharmacodynamics of vancomycin metabolism. Efficacy and
safety data are discussed. The pathophysiology of vancomycin nephrotoxicity is
considered. Risk factors for nephrotoxicity are enumerated, including the
potential synergistic nephrotoxicity of vancomycin and piperacillin-tazobactam.
Suggestions for clinical practice and future research are given.