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10.1016/j.ccell.2017.02.009

http://scihub22266oqcxt.onion/10.1016/j.ccell.2017.02.009
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suck abstract from ncbi


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pmid28292436
      Cancer+Cell 2017 ; 31 (3 ): 326-341
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  • The Microenvironmental Landscape of Brain Tumors #MMPMID28292436
  • Quail DF ; Joyce JA
  • Cancer Cell 2017[Mar]; 31 (3 ): 326-341 PMID28292436 show ga
  • The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.
  • |*Tumor Microenvironment [MESH]
  • |Blood-Brain Barrier [MESH]
  • |Brain Neoplasms/*immunology/therapy [MESH]
  • |Dendritic Cells/physiology [MESH]
  • |Humans [MESH]
  • |Macrophages/physiology [MESH]
  • |Microglia/physiology [MESH]
  • |Neovascularization, Physiologic [MESH]
  • |Neutrophils/physiology [MESH]
  • |T-Lymphocytes/immunology [MESH]


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