The MYCN Protein in Health and Disease
#MMPMID28358317
Ruiz-Pérez MV
; Henley AB
; Arsenian-Henriksson M
Genes (Basel)
2017[Mar]; 8
(4
): ? PMID28358317
show ga
MYCN is a member of the MYC family of proto-oncogenes. It encodes a transcription
factor, MYCN, involved in the control of fundamental processes during embryonal
development. The MYCN protein is situated downstream of several signaling
pathways promoting cell growth, proliferation and metabolism of progenitor cells
in different developing organs and tissues. Conversely, deregulated MYCN
signaling supports the development of several different tumors, mainly with a
childhood onset, including neuroblastoma, medulloblastoma, rhabdomyosarcoma and
Wilms' tumor, but it is also associated with some cancers occurring during
adulthood such as prostate and lung cancer. In neuroblastoma, MYCN-amplification
is the most consistent genetic aberration associated with poor prognosis and
treatment failure. Targeting MYCN has been proposed as a therapeutic strategy for
the treatment of these tumors and great efforts have allowed the development of
direct and indirect MYCN inhibitors with potential clinical use.
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