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2015 ; 31
(5
): 239-51
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The Landscape of long noncoding RNA classification
#MMPMID25869999
St Laurent G
; Wahlestedt C
; Kapranov P
Trends Genet
2015[May]; 31
(5
): 239-51
PMID25869999
show ga
Advances in the depth and quality of transcriptome sequencing have revealed many
new classes of long noncoding RNAs (lncRNAs). lncRNA classification has
mushroomed to accommodate these new findings, even though the real dimensions and
complexity of the noncoding transcriptome remain unknown. Although evidence of
functionality of specific lncRNAs continues to accumulate, conflicting,
confusing, and overlapping terminology has fostered ambiguity and lack of clarity
in the field in general. The lack of fundamental conceptual unambiguous
classification framework results in a number of challenges in the annotation and
interpretation of noncoding transcriptome data. It also might undermine
integration of the new genomic methods and datasets in an effort to unravel the
function of lncRNA. Here, we review existing lncRNA classifications,
nomenclature, and terminology. Then, we describe the conceptual guidelines that
have emerged for their classification and functional annotation based on
expanding and more comprehensive use of large systems biology-based datasets.
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